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Morphine metabolism





Morphine metabolites

6/16/2014
01:45 | Author: Sarah Gray

Morphine metabolism
Morphine metabolites

In man, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) are the major metabolites of morphine. The metabolism of morphine occurs not only.

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Morphine is a potent opioid analgesic widely used for the treatment of acute pain and for long-term treatment of severe pain. Morphine is a member of the morphinan-framed alkaloids, which are present in the poppy plant. The drug is soluble in water, but its solubility in lipids is poor. In man, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) are the major metabolites of morphine.

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Morphine Pharmacokinetics - News Medical

4/15/2014
03:50 | Author: Alex Watson

Morphine metabolism
Morphine Pharmacokinetics - News Medical

The morphine is glucuronidated by the phase II metabolism enzyme UDP-glucuronosyl transferase-2B7. The drug may also be metabolized.

Morphine is absorbed into the bloodstream via multiple routes of administration including:

Morphine is a highly potent and addictive opioid that is used widely in clinical medicine and surgery for a variety of reasons. Due to the euphoria and pleasurable effects the drug exerts, it is also widely used for recreational purposes and is commonly abused by drug addicts.

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In the case of subcutaneous injection, blood levels of morphine peak after about 20 minutes and with oral ingestion, levels peak after about 30 minutes.

By Dr Ananya Mandal, MD.

Around 90% of morphine taken is excreted from the body within 24 hours, mostly in the form of urine. Morphine has an elimination half-life of around 120 minutes. The drug can be stored in fat, so remains detectable for a long time after use and even after a person has died.

During metabolism, around 60% of morphine becomes morphine-3-glucuronide and 6% to 10% becomes morphine-6-glucuronide. The morphine is glucuronidated by the phase II metabolism enzyme UDP-glucuronosyl transferase-2B7. The drug may also be metabolized into small quantities of normorphine, codeine, and hydromorphone.

Last Updated: Oct 27, 2013.

Once morphine reaches the bloodstream, it is carried to the liver where a large proportion of it is broken down, a process termed first-pass metabolism. Due to this first-pass metabolism, only around 40% to 50% of morphine reaches the central nervous system.

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Morphine

12/24/2014
05:25 | Author: Sarah Gray

Morphine metabolism
Morphine

Morphine is a drug commonly used in the management of moderate to severe The primary site of morphine metabolism is the liver, where it undergoes rapid.

Morphine has a high systemic clearance and an accordingly short half-life of approximay two hours. The primary site of morphine metabolism is the liver, where it undergoes rapid glucuronidation. However, extrahepatic metabolism of the drug can account for up to 30% of its total clearance. This extrahepatic metabolism may play a relatively important role in morphine metabolism in patients with severe liver failure. In the liver, the principal metabolite is the morphine-3-glucuronide (M3G). This metabolite has no pharmacological effect and is primarily excreted in the urine.

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Opioid problems, and morphine metabolism and excretion - Medical

10/23/2014
03:20 | Author: Alex Watson

Dafalgan codeine effects
Opioid problems, and morphine metabolism and excretion - Medical

To make sense of morphine metabolism the structure-activity relationships must be understood. Alterations to the structure change the pharmacological activity.

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MS-Contin (Morphine Sulfate Controlled-Release) Drug Information

8/22/2014
01:15 | Author: Sarah Gray

Morphine metabolism
MS-Contin (Morphine Sulfate Controlled-Release) Drug Information

Learn about clinical pharmacology for the drug MS-Contin (Morphine Sulfate The major pathways of morphine metabolism include glucuronidation to produce.

The oral bioavailability of morphine is approximay 20 to 40%. When MS CONTIN is given on a fixed dosing regimen, steady-state is achieved in about a day.

A gender analysis of pharmacokinetic data from healthy subjects taking MS CONTIN indicated that morphine concentrations were similar in males and females.

Opioids have been shown to have a variety of effects on components of the immune system in in vitro and animal models. The clinical significance of these findings is unknown. Overall, the effects of opioids appear to be modestly immunosuppressive.

Read the Goal of Label Changes: Better Prescribing, Safer Use of Opioids article »

The effect of food upon the systemic bioavailability of MS CONTIN has not been systematically evaluated for all strengths.

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