Learn about clinical pharmacology for the drug Vicodin (Hydrocodone Bitartrate and antitussive with multiple actions qualitatively similar to those of codeine.
Approximay 85% of an oral dose appears in the urine within 24 hours of administration, most as the glucuronide conjugate, with small amounts of other conjugates and unchanged drug. See OVERDOSAGE for toxicity information.
The analgesic action of acetaminophen involves peripheral influences, but the specific mechanism is as yet undetermined. Antipyretic activity is mediated through hypothalamic heat regulating centers.