Contact your doctor or health care provider right away if any of these apply to you.
Promethazine/codeine syrup is a phenothiazine antihistamine and narcotic cough suppressant combination. The antihistamine works by blocking the action of histamine to reduce the symptoms of an allergic reaction, such as runny nose and sinus drainage. The cough suppressant works in the brain to decrease the cough reflex.
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Data sources include Micromedex (updated Sep 26th, 2014), Cerner Multum (updated Oct 16th, 2014), Wolters Kluwer (updated Oct 9th, 2014) and others. To view content sources and attributions, refer to our editorial policy.
Some medical conditions may interact with promethazine/codeine syrup. l your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); abnormal thoughts; agitation; change in the amount of urine produced; confusion; fainting; fast, slow, or irregular heartbeat; hallucinations; loss of coordination; mood or mental changes; muscle pain or stiffness; overexcitement; seizures; severe drowsiness; severe or persistent blurred vision, dizziness, headache, or lightheadedness; slow or irregular breathing; symptoms of infection (eg, fever, chills); tremors; uncontrolled muscle movements (eg, movements of the arms, legs, tongue, eyes); unusual bruising or bleeding; unusual sweating; vision problems; yellowing of the skin or eyes.
When used for long periods of time or at high doses, promethazine/codeine syrup may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if promethazine/codeine syrup stops working well. Do not take more than prescribed.
Approval History Calendar Drug history at FDA.
Contact (the American Association of Poison Control Centers), your local poison control center, or emergency room immediay. Symptoms may include cold or clammy skin; coma; dilated or pinpoint pupils; exaggerated reflexes; limp or rigid muscles; loss of consciousness; seizures; severe dizziness; severe drowsiness; slow or difficult breathing; slow or irregular heartbeat.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
Cough Benadryl Dilaudid diphenhydramine acetaminophen/hydrocodone benzonatate hydromorphone Lortab codeine Tylenol with Codeine #3 guaifenesin Mucinex dextromethorphan acetaminophen/codeine Cheratussin AC Tessalon Perles Promethazine with Codeine Tessalon Promethazine DM Tussionex Pennkinetic Hycodan Robitussin Cough + Chest Congestion DM Hydromet Robitussin-AC Tylenol with Codeine Mucinex DM More.
Some children have had serious and sometimes fatal breathing problems when using codeine after surgery to remove tonsils or adenoids. Talk with your doctor for more information.
Use promethazine/codeine syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use promethazine/codeine syrup.
Generic Name: promethazine/codeine (proe-METH-a-zeen/KOE-deen) Brand Name: Generic only. No brands available.
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Pregnancy Category C Risk cannot be ruled out.
Some people who use promethazine/codeine syrup for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. If you stop taking promethazine/codeine syrup suddenly, you may have WITHDRAWAL symptoms. These may include anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea and vomiting; pain; rigid muscles; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; or trouble sleeping.
Some MEDICINES MAY INTERACT with promethazine/codeine syrup. l your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if promethazine/codeine syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Blurred vision; constipation; dizziness; drowsiness; dry mouth, throat, or nose; headache; nausea; tiredness or weakness; vomiting.
Store promethazine/codeine syrup at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep promethazine/codeine syrup out of the reach of children and away from pets.
Promethazine/codeine syrup may cause severe and sometimes fatal breathing problems in children. Do NOT use promethazine/codeine syrup in children younger than 6 years old. Do not give promethazine/codeine syrup with any other medicines that can cause breathing problems.
Treating cough and other upper respiratory symptoms caused by allergies or the common cold. It may also be used for other conditions as determined by your doctor.
CSA Schedule 5 Some potential for abuse.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
Availability Rx Prescription only.
This information should not be used to decide whether or not to take promethazine/codeine syrup or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about promethazine/codeine syrup. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to promethazine/codeine syrup. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using promethazine/codeine syrup.