Getmedicin.org

Codeine metabolism time





Disposition and metabolism of codeine after single and chronic

02/04/2015
11:39 | Author: Tyler James

Codeine metabolism time
Disposition and metabolism of codeine after single and chronic

The pharmacokinetics, metabolism and partial clearances of codeine to morphine, After the single dose, the time to achieve maximum plasma codeine.

National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

Warning: The NCBI web site requires JavaScript to function. more.

1. The pharmacokinetics, metabolism and partial clearances of codeine to morphine, norcodeine and codeine-6-glucuronide after single (30 mg) and chronic (30 mg 8 h for seven doses) administration of codeine were studied in eight subjects (seven extensive and one poor metaboliser of dextromethorphan).

Comments (1)Read more



Pharmacogenetics of codeine metabolism in an urban population of

02/04/2015
09:18 | Author: Hannah Ramirez

Codeine metabolism time
Pharmacogenetics of codeine metabolism in an urban population of

Reduced ability for codeine metabolism may be more common than previously Both groups also received diclofenac 1 mg kg–1 per rectum at the same time.

Phenotype distribution (type of metabolizer).

Fig 2 Relationship between plasma morphine, metabolites and phenotype for patients treated with codeine. P=poor metabolizers; IM/P=intermediate/poor metabolizers; E=extensive metabolizers.

Comments (2)Read more

Detection of Acetylcodeine in Urine as an Indicator of Illicit Heroin

02/04/2015
07:23 | Author: Sarah Gray

Codeine metabolism time
Detection of Acetylcodeine in Urine as an Indicator of Illicit Heroin

Detection times were determined for AC and codeine by parallel 1⇓ , both codeine and heroin are metabolized into morphine, which is then excreted in the.

Background: Acetylcodeine (AC), an impurity of illicit heroin synthesis, has been suggested as an interesting biomarker of illicit heroin use.

The role of AC in urine as a specific indicator of illicit heroin use depends on two main factors: (a) the availability of a reliable and sensitive analytical method for AC detection and, subsequently, availability of other opiate detection methods; and ( b ) an adequate detection time for AC and codeine in urine.

Comments (3)Read more