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Codeine metabolism rate





Health - Codeine and metabolism - Drugs Forum

02/04/2015
07:08 | Author: Hannah Ramirez

Codeine metabolism time
Health - Codeine and metabolism - Drugs Forum

Opiates like codeine and other opiates (morphine) & opioids slow metabolism by affecting the GI tract. Everyone has opioid receptors within.

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Genetic Factors In Drug Metabolism - American Family Physician

02/04/2015
05:44 | Author: Emily Peterson

Codeine metabolism rate
Genetic Factors In Drug Metabolism - American Family Physician

The main routes of drug elimination are metabolism (often in the liver) and. acid suppression and higher cure rates than the rest of the population. Codeine is metabolized by CYP2D6 to its active metabolite, morphine.

18 to 23 3, 5.

Statins (pravastatin) Fibrates (gemfibrozil).

29 7, 8 18 7 Ultrarapid — — — CYP2D6 Poor.

1.0 to 4.8 3, 5, 8.

ACE = angiotensin-converting enzyme; ARB = angiotensin receptor blocker; FEV 1 = forced expiratory volume in one second; HDL = high-density lipoprotein; LDL = low-density lipoprotein.

Greater reduction in blood pressure and left ventricle mass with ACE inhibitors and ARBs 19 Apolipoprotein E Statins (simvastatin ).

The activity of drug-metabolizing enzymes may be induced or inhibited by many other intrinsic and extrinsic factors, including comorbid conditions, use of other medications, smoking, alcohol intake, and dietary factors.

note: Poor metabolizers have markedly reduced or absent enzyme activity; intermediate metabolizers have reduced enzyme activity; and ultrarapid metabolizers have high enzyme activity.

Information from references 3 through 9.

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