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Codeine allergic reaction





Codeine induces human mast cell chemokine and cytokine

12/16/2014
03:13 | Author: Tyler James

Codeine allergic reaction
Codeine induces human mast cell chemokine and cytokine

Although degranulation and release of histamine by human skin mast cells can account for many of the symptoms associated with codeine allergy, it is possible.

Cytokine and chemokine production by human mast cells induced by IgE and antigen is dependent upon activation of MAP kinases ( 13 ). We measured MAP kinase phosphorylation in human mast cells following codeine stimulation to determine the role of MAP kinases. LAD2 cells were stimulated with 2.5 μg/ml of codeine for 5–30 min and phosphorylation of ERK, JNK, and p38 was measured using Western blot. After 5 min of stimulation, codeine activated ERK and JNK phosphorylation ( Fig. 5A ).

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Narcotic Allergies WhiteCoat39s Call Room

10/15/2014
01:34 | Author: Emily Peterson

Codeine allergic reaction
Narcotic Allergies WhiteCoat39s Call Room

meperidine < codeine < morphine < hydrocodone < oxycodone < hydromorphone < fentanyl. If the patient describes a true allergy to an opiate.

Opioid Allergy True anaphylactic reactions to opioids are very rare. When patients say they are allergic to an opiod, it is much more likely that the patient has experienced GI upset or a pseudoallergy. Flushing, itching, hives, and sweating, especially itching or flushing at the injection site only, suggests a pseudoallergy due to histamine release, a pharmacologic side effect of some opioids. Codeine, morphine, and meperidine are the opioids most commonly associated with pseudoallergy.

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