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Effects of codeine





Erowid Codeine Vault FAQ

9/22/2014
07:10 | Author: Alex Watson

Is codeine an opiate
Erowid Codeine Vault FAQ

Codeine is mainly used as a pain reliever, but is also used for the relief of a non-productive cough, and as a anti-diarrheal.

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(codeine) dosing, indications, interactions, adverse effects, and more

7/21/2014
05:20 | Author: Alex Watson

Effects of codeine
(codeine) dosing, indications, interactions, adverse effects, and more

Medscape - Antitussive, pain-specific dosing for (codeine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy.

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Pharmacogenetic determination of the effects of codeine and

5/20/2014
03:30 | Author: Alex Watson

Effects of codeine
Pharmacogenetic determination of the effects of codeine and

Pharmacogenetic determination of the effects of codeine and prediction of drug interactions. Caraco Y, Sheller J, Wood AJ. To define the differences in codeine.

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To define the differences in codeine pharmacodynamics in extensive (EMs) and poor (PMs) metabolizers of debrisoquin and to determine whether the inhibition of codeine's metabolism by quinidine produces phenotypically dependent pharmacodynamic changes, we studied 16 healthy nonsmoking males, 10 EMs and 6 PMs of debrisoquin. The subjects received in random double-blind fashion 120 mg of codeine plus placebo, 120 mg of codeine plus 100 mg of quinidine and 100 mg of quinidine plus placebo. Blood was obtained over 24 hr and urine was collected for 48 hr. Respiratory, psychomotor and pupillary effects of codeine were greater in the EMs than in the PMs (P <. 01). Morphine and morphine metabolites were detectable only in plasma from EMs. Codeine metabolic clearance by O-demethylation was almost 200-fold greater in the EMs than in the PMs. After coadministration of quinidine, morphine and morphine metabolites were not detectable in the plasma of either phenotype and mean (+/- S.E.M.) O-demethylation clearance was reduced in the EMs from 162.7 +/- 36.6 to 17.0 +/- 5.0 ml/min (P <. 003), but not in the PMs. The diminished production of morphine in the EMs was associated with significantly reduced respiratory, psychomotor and pupillary effects (P <. 01). Thus, CYP2D6 mediated O-demethylation of codeine to morphine is central to its pharmacodynamic effects. Patients who lack CYP2D6 or whose CYP2D6 is inhibited would not be expected to benefit from codeine. Thus, phenotyping for CYP2D6 and the avoidance of CYP2D6 inhibitors is justified in patients with chronic path before initiating long-term therapy with analgesics whose in vivo activation is dependent on CYP2D6 activity (i.e., codeine, hydrocodone and oxycodone.

National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

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Codeine phosphate tablets

3/19/2014
01:20 | Author: Alex Watson

Effects of codeine
Codeine phosphate tablets

These people are more likely to experience side effects after taking codeine, because they convert more codeine into morphine than other.

Codeine phosphate can reduce the muscular activity in the gut and so may oppose the effect of the following medicines on the gut:

In treating diarrhoea, codeine works by acting on opioid receptors that are found in the muscles lining the walls of the intestines. This reduces the muscular contractions of the intestine (called peristalsis) that move food and faecal matter through the gut.

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Long Term Effects of Codeine - Codeine rehab

1/18/2014
01:10 | Author: Alex Watson

Effects of codeine
Long Term Effects of Codeine - Codeine rehab

Codeine has a long list of possible side effects, which can be divided into two main categories; long term effects and short term effects of codeine use. Long term.

Many of these long term effects of codeine use make everyday life a struggle, but you can get help. But the first step is getting clean. Once you are no longer using codeine, some of these effects will dissipate, and become less noticeable over time.

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