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Codeine narcotic





Tylenol-Codeine (Acetaminophen and Codeine) Drug Information

10/15/2014
02:06 | Author: Hannah Ramirez

Codeine narcotic
Tylenol-Codeine (Acetaminophen and Codeine) Drug Information

In the presence of head injury or other intracranial lesions, the respiratory depressant effects of codeine and other narcotics may be markedly enhanced, as well.

A study in rats and rabbits reported no teratogenic effect of codeine administered during the period of organogenesis in doses ranging from 5 to 120 mg/kg. In the rat, doses at the 120 mg/kg level, in the toxic range for the adult animal, were associated with an increase in embryo resorption at the time of implantation. In another study a single 100 mg/kg dose of codeine administered to pregnant mice reportedly resulted in delayed ossification in the offspring.

Codeine or other narcotics may obscure signs on which to judge the diagnosis or clinical course of patients with acute abdominal conditions.

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In the presence of head injury or other intracranial lesions, the respiratory depressant effects of codeine and other narcotics may be markedly enhanced, as well as their capacity for elevating cerebrospinal fluid pressure.

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Central and peripheral mechanisms of narcotic antitussives codeine

8/14/2014
12:28 | Author: Hannah Ramirez

Codeine narcotic
Central and peripheral mechanisms of narcotic antitussives codeine

Narcotic antitussives such as codeine reveal the antitussive effect primarily via the μ-opioid receptor in the central nervous system (CNS).

In a chronic bronchitis model of rats produced by SO 2 gas exposure, SP content in the trachea was elevated. In a similar model using guinea pigs, codeine did not inhibit the cough responses elicited by mechanical stimulation of the larynx side of the trachea or the tracheal bifurcation. Epithelial shedding was not observed, but neutral endopeptidase (NEP) levels and NEP activity in the trachea and bronchus were significantly lower than those of normal guinea pigs. NEP degrades a variety of peptides, including bradykinin, SP and other tachykinins.

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Studies on the effects of the narcotic alkaloids, cocaine, morphine

6/13/2014
02:58 | Author: Alex Watson

Codeine narcotic
Studies on the effects of the narcotic alkaloids, cocaine, morphine

Biochem Med Metab Biol. 1987 Apr;37(2):258-64. Studies on the effects of the narcotic alkaloids, cocaine, morphine, and codeine on nonenzymatic lipid.

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This paper presents evidence of studies on the effects of the narcotic alkaloids, cocaine hydrochloride, morphine sulfate, and codeine phosphate, on nonenzymatic lipid peroxidation in rat brain mitochondria. These organelles abound in polyunsaturated fatty acids and are thus susceptible to oxidative attack. Lipid peroxidation was indexed mainly by assaying the extent of malonaldehyle (MDA) production and also the formation of fluorescent products in the course of the reaction. We found that morphine sulfate lowered fluorescence while the other two alkaloids showed no effect on lipid peroxidation in the absence of the inducers, 1.0 mM ascorbic acid or 0.1 mM ferrous sulfate. The apparent antioxidative nature of morphine sulfate was also observed in its effects on induced and noninduced MDA production, both cocaine hydrochloride and codeine phosphate stimulated MDA production by about 20% in the absence of any inducers. This paper also attempts to draw a structure-activity relationship for the antioxidative action of opium alkaloids, which we postulated to be due to the chelating capability of the alkaloid molecule.

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Opioid - Narcotic - Converter - Globalrph

4/12/2014
04:36 | Author: Emily Peterson

Does percocet contain codeine
Opioid - Narcotic - Converter - Globalrph

Opioid (Narcotic) analgesic converter. Note: ALL METHADONE CALCULATIONS REMOVED - Check out the new advanced version for.

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Narcotic Analgesic Drugs - Chemwiki

2/11/2014
06:10 | Author: Alex Watson

Codeine narcotic
Narcotic Analgesic Drugs - Chemwiki

Morphine exerts a narcotic action manifested by analgesia, drowsiness, changes in mood, and mental clouding.

Opium contains over 20 compounds but only morphine (10%) and codeine (0.5%) are of any importance. Morphine is extracted from the opium and isolated in a relatively pure form. Since codeine is in such low concentration, it is synthesized from morphine by an ether-type methylation of an alcohol group. Codeine has only a fraction of the potency compared to morphine. It is used with aspirin and as a cough suppressant.

A schematic for an analgesic receptor site may look as shown in the graphic below with morphine.

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