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Codeine pain killer





Why codeine painkillers don39t work for millions - and may even harm

6/13/2014
04:40 | Author: Alex Watson

Codeine pain killer
Why codeine painkillers don39t work for millions - and may even harm

Agony: Dr Paul Debenham suffers from an enzyme deficiency that can't metabolise the painkiller codeine to break it down into morphine.

There are some 25 others including the opioid painkiller tramadol, certain antidepressants known as selective serotonin re-uptake inhibitors, or SSRIs, which include Prozac and Zoloft, and antipsychotic drugs used to treat mental illness.

Common issue: It is estimated that between seven and ten per cent of the population cannot break down codeine.

Indeed as Dr Knaggs points out, ‘even if you don’t have a problem with production of the CYP2D6 enzyme, codeine still might not work for you, as drug response in pain is such a complex process’

‘It may be money well spent in cases where patients have a pain condition,’ he says.

Dr Johnson suggests that there may be even more fast metabolisers than non-metabolisers — and that put together they could amount to about 30 per cent of the population.

Published by Associated Newspapers Ltd.

‘Patients often keep taking codeine in the vain hope that it will work eventually — but all they experience are the side-effects, such as constipation (it slows down gut movement in the intestine) and none of the pain-relieving benefits,’ says Dr Johnson.

Now, in a larger study, 50 men will have monthly sessions of the treatment over a year.

‘Screening could determine how well other drugs work, too.

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Are you taking the right painkiller? Daily Mail Online

4/12/2014
02:40 | Author: Alex Watson

Codeine pain killer
Are you taking the right painkiller? Daily Mail Online

Codeine - related to morphine - is often combined with paracetamol, ibuprofen or aspirin. This combination helps boost the painkiller which does not have any.

by NAOMI COLEMAN, Daily Mail.

Risks: Avoid doubling up on aspirin and ibuprofen as these combinations are often found in cold and flu preparations.

Main brands: Nurofen is one of the leading brand names for ibuprofen - and Anadin is one of the leading brand names for aspirin.

Main brands: Nurofen plus (ibuprofen with codeine), solpadeine (paracetamol with codeine) and feminax (aspirin and codeine).

Codeine blocks pain receptors found at the end of nerves in our bodies.

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Codeine painkillers are 39unsafe, addictive and ineffective39 warn

12/21/2014
10:40 | Author: Alex Watson

Codeine pain killer
Codeine painkillers are 39unsafe, addictive and ineffective39 warn

Some 27million packs of codeine-containing painkillers are sold Tens of thousands are thought to be hooked on over-the-counter medication containing it, Some people will produce little morphine and also get little pain.

Chief executive Sheila Kelly said a recent review of over-the-counter medicines containing codeine concluded that used properly they were ‘very effective and acceptably safe medicines’

‘For infants and young children in particular, this can be deadly.’

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But others will make large amounts of morphine, putting them at risk of overdose, with children particularly vulnerable.

Many of the safety concerns surround the unpredictability of the way the body handles codeine, which has no effect on pain until it is broken down by the liver to produce morphine.

By Fiona Macrae for the Daily Mail Updated: 02:55 GMT, 23 October 2010 147 View comments.

They say that over-the-counter painkillers and cough mixtures containing codeine used by millions may be unsafe, addictive, ineffective, and should not be used by children.

An editorial says: ‘Because codeine has been in common use for over 200 years, it was never subjected to the regulatory requirement for the rigorous safety studies that are mandatory for new drugs.

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‘All of these genetic variations can have potentially serious clinical consequences.

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Painkillers for Treating Pain and Inflammation - Disabled World

10/20/2014
08:00 | Author: Alex Watson

Codeine pain killer
Painkillers for Treating Pain and Inflammation - Disabled World

List of painkillers and stronger analgesics like codeine used to treat moderate A Painkiller (also called pain killers, pain medications, pain.

List of painkillers and stronger analgesics like codeine used to treat moderate and severe pain including anti-inflammatory drugs and morphine. A Painkiller (also called pain killers, pain medications, pain relievers) and medically known as an Analgesic is defined as a drug used to relieve pain, or achieve analgesia, by blocking pain signals going to the brain or by interfering with the brain's interpretation of the signals.

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Codeine Painkiller that changes form once it39s inside the body

8/19/2014
06:40 | Author: Alex Watson

Codeine pain killer
Codeine Painkiller that changes form once it39s inside the body

The name "codeine" comes from the Greek word kodeia, meaning "poppy head". It has been traditionally prepared from the opium poppy for.

Sunday 19 October 2014.

Although codeine can be extracted directly from the opium poppy, most commercially available products are made by altering the chemical structure of morphine to produce purified codeine for use as a general painkiller.

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This has led some scientists to question whether codeine can be given in doses that will always be effective or safe.

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