Acetaminophen may produce false-positive test results for urinary 5-hydroxyindoleacetic acid.
Gastrointestinal : difficulty swallowing, heartburn, flatulence, constipation.
Several cases of dermatological reactions, including toxic epidermal necrolysis and erythema multiforme, have been reported.
"The U.S. Food and Drug Administration today allowed marketing of the Cerena Transcranial Magnetic Stimulator (TMS), the first device to relieve pain caused by migraine headaches that are preceded by an aura: a visual, sensory or motor disturbance".
Cardiovascular : tachycardia.
Acetaminophen : allergic reactions, rash, thrombocytopenia, agranulocytosis.
Last reviewed on RxList: 8/8/2011 This monograph has been modified to include the generic and brand name in many instances. Share this Article:
Read the Fioricet Drug Interactions Center for a complete guide to possible interactions.
Autonomic Nervous System : dry mouth, hyperhidrosis.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
The most frequently reported adverse reactions are drowsiness, lightheadedness, dizziness, sedation, shortness of breath, nausea, vomiting, abdominal pain, and intoxicated feeling.
Central Nervous System : headache, shaky feeling, tingling, agitation, fainting, fatigue, heavy eyelids, high energy, hot spells, numbness, sluggishness, seizure. Mental confusion, excitement, or depression can also occur due to intolerance, particularly in elderly or debilitated patients, or due to overdosage of butalbital.
Barbiturates may be habit-forming: Tolerance, psychological dependence, and physical dependence may occur especially following prolonged use of high doses of barbiturates. The average daily dose for the barbiturate addict is usually about 1500 mg. As tolerance to barbiturates develops, the amount needed to maintain the same level of intoxication increases; tolerance to a fatal dosage, however, does not increase more than two-fold. As this occurs, the margin between an intoxication dosage and fatal dosage becomes smaller. The lethal dose of a barbiturate is far less if alcohol is also ingested. Major withdrawal symptoms (convulsions and delirium) may occur within 16 hours and last up to 5 days after abrupt cessation of these drugs. Intensity of withdrawal symptoms gradually declines over a period of approximay 15 days. Treatment of barbiturate dependence consists of cautious and gradual withdrawal of the drug. Barbiturate-dependent patients can be withdrawn by using a number of different withdrawal regimens. One method involves initiating treatment at the patient's regular dosage level and gradually decreasing the daily dosage as tolerated by the patient.
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Butalbital, acetaminophen, and caffeine may enhance the effects of: other narcotic analgesics, alcohol, general anesthetics, tranquilizers such as chlordiazepoxide, sedative-hypnotics, or other CNS depressants, causing increased CNS depression.
FDA Allows Marketing of First Device to Relieve Migraine Headache Pain »
All adverse events tabulated below are classified as infrequent.
The following adverse drug events may be borne in mind as potential effects of the components of this product. Potential effects of high dosage are listed in the OVERDOSAGE section.
The CNS effects of butalbital may be enhanced by monoamine oxidase (MAO) inhibitors.
Read the Fioricet (butalbital, acetaminophen and caffeine) Side Effects Center for a complete guide to possible side effects.
Miscellaneous : pruritus, fever, earache, nasal congestion, tinnitus, euphoria, allergic reactions.
Musculoskeletal : leg pain, muscle fatigue.
Genitourinary : diuresis.
Caffeine : cardiac stimulation, irritability, tremor, dependence, nephrotoxicity, hyperglycemia.